Fig. 1
From: Non-coding RNAs regulation of macrophage polarization in cancer
Advanced subtypes of M2 macrophage based on their roles in tumor microenvironment. M2a is known to be induced by IL-13, IL-4 and helps in tissue repair and wound healing. M2b is induced by IC, TLRs, IL-1R and helps in anti-inflammatory effects and immunoregulation. M2c is induced by IL-10 and glucocorticoid and helps in tissue repair and wound healing. M2d is induced by leukemia inhibitory factor (LIF), IL-6, adenosine and helps in the induction of angiogenesis and tumor progression