Non-coding RNAs regulation of macrophage polarization in cancer

Mohapatra, Swati; Pioppini, Carlotta; Ozpolat, Bulent; Calin, George A.

doi:10.1186/s12943-021-01313-x

Molecular Cancer

Table 2 Summary of all the ncRNAs that are currently reported to be involved in regulating macrophage polarization in different types of cancer

From: Non-coding RNAs regulation of macrophage polarization in cancer

*ncRNA*	Cancer type	Macrophage polarization	Targets/signaling pathways	Categorization	Reference
*miR-34-a*	BC	Promote M1 Polarization, Inhibit M2 Polarization	IL-6R, STAT3	Juggling Tumor Suppressor	[44, 45]
*miR-16*	BC	Promote M1 Polarization, Inhibit M2 Polarization	IL-6, TGFβ, TNFα	Juggling Tumor Suppressor	[39]
*miR-503*	BC	Promote M2 Polarization, Inhibit M1 Polarization	STAT3 phosphorylation, NF-kB	Juggling Oncogene	[55]
*miR-19a-3p*	BC	Promote M2 Polarization	Fra-1 proto-oncogene, TNFα, NF-kB	Oncogene	[40, 41]
*lncRNA GNAS-AS1*	BC, NSCLC	Promote M2 Polarization	p53	Oncogene	[82, 83]
*LincRNA p21*	BC	Promote M2 Polarization	miR-1303 sponging, PTBP3	Oncogene	[101,102,103,104]
*lncRNA BCRT1*	BC	Promote M2 Polarization	miR-433-3p sponging, IL-10 and Arg-1	Oncogene	[65]
*miR-Let-7b*	PC	Promote M2 Polarization	IL-12, IL-23, TNFα	Oncogene	[58,59,60,61,62]
*miR-224*	PC	Promote M2 Polarization	TRIB1, IKB-zeta	Oncogene	[52, 53]
*lncRNA CCAT1*	PC	Promote M1 Polarization, Inhibit M2 Polarization	lncRNA CCAT1/miR-148a/PKCζ axis	Juggling Tumor Suppressor	[66,67,68]
*miR-301a-3p*	PANC	Promote M2 Polarization	PTEN/PI3Kgamma	Oncogene	[54, 117]
*miR-155*	PANC, leukemia	Promote M1 Polarization	C/EBPβ	Tumor Suppressor	[48,49,50]
*miR-1246*	glioma, OC	Promote M2 Polarization	NF-kB-STAT3-TERF2IP axis	Oncogene	[56]
*miR-142-3p*	glioma	Promote M1 Polarization	TGF-β	Tumor Suppressor	[46, 118]
*lncRNA LINC00662*	HCC	Promote M2 Polarization	Wnt/β-catenin	Oncogene	[84, 85, 88]
*lncRNA MALAT1*	HCC	Promote M2 Polarization, Inhibit M1 Polarization	miR-140, VEGF-A	Juggling Oncogene	[92, 93]
*lncRNA TUC339*	HCC	Promote M2 Polarization	IL-1 β, TNFα	Oncogene	[109, 110]
*lncRNA COX-2*	HCC	Promote M1 Polarization, Inhibit M2 Polarization	IL-12, iNOS, and TFN-alpha(M1), Arg-1, IL-10, and Fizz-1(M2)	Juggling Tumor Suppressor	[71, 72]
*miR-145*	CRC	Promote M2 Polarization	IL-12p40, IL-10, HDAC11	Oncogene	[47]
*miR-195-5p*	CRC	Promote M2 Polarization	miR-195-5p/NOTCH2-GATA3/IL-4 axis	Oncogene	[51]
*lncRNA GAS5*	CRC	Promote M1 Polarization, Inhibit M2 Polarization	IRF4	Juggling Tumor Suppressor	[75, 76]
*lncRNA RPPH1*	CRC	Promote M2 Polarization	TUBB3	Oncogene	[105,106,107]
*lncRNA MM2P*	OS	Promote M2 Polarization	STAT6	Oncogene	[94]
*lncRNA RP11-361F15.2*	OS	Inhibit M2 Polarization	miR-30c-5p, CPEB4	Tumor Suppressor	[108]
*miR-29a-3p*	OSCC	Promote M2 Polarization	SOCS1/STAT6 signaling	Oncogene	[43]
*miR-21*	HNC	Promote M2 Polarization	PDCD4, IL12A	Oncogene	[42]
*lncRNA NIFK-AS1N*	EC	Promote M1 Polarization, Inhibit M2 Polarization	NIFK-AS1/miR-146a/NOTCH1 axis	Juggling Tumor Suppressor	[99]
*lncRNA ANCR*	GC	Inhibit M1 Polarization	FOXO1	Oncogene	[63]
*lncRNA NEAT1*	MM	Promote M2 Polarization	lncRNA NEAT1/miR-214/B7-H3/JAK2-STAT3 axis	Oncogene	[95, 96]
*lncRNA XIST*	LC	Promote M2 Polarization	IL-4, TCF-4	Oncogene	[111, 114]

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