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Table 2 Summary of all the ncRNAs that are currently reported to be involved in regulating macrophage polarization in different types of cancer

From: Non-coding RNAs regulation of macrophage polarization in cancer

ncRNA Cancer type Macrophage polarization Targets/signaling pathways Categorization Reference
miR-34-a BC Promote M1 Polarization, Inhibit M2 Polarization IL-6R, STAT3 Juggling Tumor Suppressor [44, 45]
miR-16 BC Promote M1 Polarization, Inhibit M2 Polarization IL-6, TGFβ, TNFα Juggling Tumor Suppressor [39]
miR-503 BC Promote M2 Polarization, Inhibit M1 Polarization STAT3 phosphorylation, NF-kB Juggling Oncogene [55]
miR-19a-3p BC Promote M2 Polarization Fra-1 proto-oncogene, TNFα, NF-kB Oncogene [40, 41]
lncRNA GNAS-AS1 BC, NSCLC Promote M2 Polarization p53 Oncogene [82, 83]
LincRNA p21 BC Promote M2 Polarization miR-1303 sponging, PTBP3 Oncogene [101,102,103,104]
lncRNA BCRT1 BC Promote M2 Polarization miR-433-3p sponging, IL-10 and Arg-1 Oncogene [65]
miR-Let-7b PC Promote M2 Polarization IL-12, IL-23, TNFα Oncogene [58,59,60,61,62]
miR-224 PC Promote M2 Polarization TRIB1, IKB-zeta Oncogene [52, 53]
lncRNA CCAT1 PC Promote M1 Polarization, Inhibit M2 Polarization lncRNA CCAT1/miR-148a/PKCζ axis Juggling Tumor Suppressor [66,67,68]
miR-301a-3p PANC Promote M2 Polarization PTEN/PI3Kgamma Oncogene [54, 117]
miR-155 PANC, leukemia Promote M1 Polarization C/EBPβ Tumor Suppressor [48,49,50]
miR-1246 glioma, OC Promote M2 Polarization NF-kB-STAT3-TERF2IP axis Oncogene [56]
miR-142-3p glioma Promote M1 Polarization TGF-β Tumor Suppressor [46, 118]
lncRNA LINC00662 HCC Promote M2 Polarization Wnt/β-catenin Oncogene [84, 85, 88]
lncRNA MALAT1 HCC Promote M2 Polarization, Inhibit M1 Polarization miR-140, VEGF-A Juggling Oncogene [92, 93]
lncRNA TUC339 HCC Promote M2 Polarization IL-1 β, TNFα Oncogene [109, 110]
lncRNA COX-2 HCC Promote M1 Polarization, Inhibit M2 Polarization IL-12, iNOS, and TFN-alpha(M1), Arg-1, IL-10, and Fizz-1(M2) Juggling Tumor Suppressor [71, 72]
miR-145 CRC Promote M2 Polarization IL-12p40, IL-10, HDAC11 Oncogene [47]
miR-195-5p CRC Promote M2 Polarization miR-195-5p/NOTCH2-GATA3/IL-4 axis Oncogene [51]
lncRNA GAS5 CRC Promote M1 Polarization, Inhibit M2 Polarization IRF4 Juggling Tumor Suppressor [75, 76]
lncRNA RPPH1 CRC Promote M2 Polarization TUBB3 Oncogene [105,106,107]
lncRNA MM2P OS Promote M2 Polarization STAT6 Oncogene [94]
lncRNA RP11-361F15.2 OS Inhibit M2 Polarization miR-30c-5p, CPEB4 Tumor Suppressor [108]
miR-29a-3p OSCC Promote M2 Polarization SOCS1/STAT6 signaling Oncogene [43]
miR-21 HNC Promote M2 Polarization PDCD4, IL12A Oncogene [42]
lncRNA NIFK-AS1N EC Promote M1 Polarization, Inhibit M2 Polarization NIFK-AS1/miR-146a/NOTCH1 axis Juggling Tumor Suppressor [99]
lncRNA ANCR GC Inhibit M1 Polarization FOXO1 Oncogene [63]
lncRNA NEAT1 MM Promote M2 Polarization lncRNA NEAT1/miR-214/B7-H3/JAK2-STAT3 axis Oncogene [95, 96]
lncRNA XIST LC Promote M2 Polarization IL-4, TCF-4 Oncogene [111, 114]