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Fig. 2 | Molecular Cancer

Fig. 2

From: Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades

Fig. 2

Chemotherapeutics drive cancer-immunity cycles. Chemotherapeutics induce immunogenic cell death (a), promote CD8+ T cell infiltration (b), and inhibit immunosuppressive cells (c). ATP: adenosine-triphosphate, BRAF: B-Raf proto-oncogene, serine/threonine kinase, CTL: Cytotoxic T lymphocytes, CXCL10: C-X-C motif chemokine ligand 10, DC: dendritic cells, HMGB1: high-mobility group box1, ICAM-1: intercellular adhesion molecule, IFN-γ: interferon-gamma, MDSC: myeloid-derived suppressor cell, NK cells: natural killer cells, PARP: Poly (ADP-ribose) polymerase, TAM: tumor-associated macrophage, TKI: tyrosine kinase inhibitor, TLS: Tertiary lymphoid structures, TNF: tumor necrosis factor, Treg: regulatory T cell, VCAM: vascular cell adhesion molecule

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