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Fig. 2 | Molecular Cancer

Fig. 2

From: Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Fig. 2

Patterns of RNA modification and biological characteristics of each pattern. a Heatmap shows a positive (red) and negative (blue) correlation among RNA modification “writers” in CRC. *p < 0.05, **p < 0.01, and ***p < 0.001, as determined by the Spearman correlation analysis. b Unsupervised clustering of 26 RNA modification “writers”. The clusters of CRC cohorts and RNA modification type were used as sample annotations. Red, high expression of “writers”; blue, low expression. c A heatmap visualizing the GSVA enrichment analysis shows the activation states of biological pathways in distinct RNA modification patterns. Red, activated pathways; blue, inhibited pathways. The names of CRC cohorts were used as sample annotations. d Kaplan-Meier curves compare overall survival between two RNA modification patterns, Cluster_1 (red) and Cluster_2 (blue), in GSE39582. The grouping of CRC samples is shown at the bottom of the chart. p < 0.05 in the two-sided log-rank test was considered statistically significant. e The difference in the relative abundance of immune cell infiltration in TME between RNA modification Cluster_1 and RNA modification Cluster_2 was calculated by the CIBERSORT algorithm. Difference > 0 indicates that the immune cells were enriched in RNA modification Cluster_1, and the column color represents the statistical significance of the difference. f-g The difference of immune cell infiltration (f) and expression of macrophage marker genes (g) between RNA modification patterns. The upper bar graph shows the number of datasets that differ significantly between Cluster_1 and Cluster_2. The color of the bubble below the graph indicates the difference in each of the distinct GEO datasets, and the bubble size indicates the statistical significance of the difference. Difference > 0 indicates that the infiltration of immune cells (f) or expression of macrophage marker genes (g) were higher in RNA modification Cluster_1

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