Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Fig. 5

Transcriptional and post-transcriptional characteristics associated with the WM_Score. a Differences in miRNA-targeted signaling pathways in the TCGA-COAD/READ cohort between the WM_Score-high and -low groups. The red line represents a low expression of miRNA in the high WM_Score group, and the blue line represents a high expression of miRNA in the low WM_Score group. Red dots correspond to miRNA-targeted genes highly expressed in the high WM_Score group, and blue dots correspond to miRNA-targeted genes highly expressed in the low WM_Score group. The circle represents a signaling pathway enriched with targeted genes. b The differences in the distal poly(A) site usage index (PDUI) of each gene between WM_Score-high and -low groups. Red, PDUI lengthening; blue, PDUI shortening; Grey, no significant change in PDUI. c Kaplan-Meier curves show overall survival between PDUI lengthening (red) and PDUI shortening (blue) of YBX2 and HEATR3. The grouping of CRC samples is shown at the bottom of the chart. p < 0.05 in the two-sided log-rank test was considered statistically significant. d The frequency of A-I editing was compared between WM_Score-high and -low groups. Red, high A-I editing; blue, low A-I editing; grey, no significant change in A-I editing. e Kaplan-Meier curves show overall survival between PDUI lengthening (red) and PDUI shortening (blue) of NUP43 and KCNE3. The grouping of CRC samples is shown at the bottom of the chart. p < 0.05 in the two-sided log-rank test was considered statistically significant

Back to article page