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Fig. 6 | Molecular Cancer

Fig. 6

From: Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Fig. 6

The relationship between WM_Score and drug sensitivity and efficacy of immunotherapy. The correlation between WM_Score and drug sensitivity evaluated by the Spearman analysis. Each column represents a drug. The brightness of the column indicates the significance of the correlation. The height of the column indicates the correlation, indicates that WM_Score related to drug resistance (Rs > 0) or drug sensitive (Rs < 0) to WM_Score. b Signaling pathways targeted by drugs that are resistant (red) or sensitivity (blue) to the WM_Score. Drug names are listed on the horizontal axis and the signaling pathway targeted by the drug on the vertical axis. The bar graph on the right shows the number of drugs targeting each signaling pathway. The size of the point indicates the significance of the correlation. c, i Kaplan-Meier curves show overall survival in the WM_Score-high (red) and -low (blue) subgroups after the PD-L1 blockade immunotherapy in the IMvigor210 (c) and anti-PD-L1 (i) cohort. The grouping of patients is shown at the bottom of the chart. p < 0.05 in the two-sided log-rank test was considered statistically significant. d The difference in the WM_Score between distinct clinical outcomes of anti-PD-L1 treatment in the IMvigor210 cohort. e The proportion of patients in the IMvigor210 cohort with different responses to PD-L1 blockade immunotherapy. The fisher.test was used to determine the statistical significance of the difference. SD, stable disease; PD, progressive disease; CR, complete response; PR, partial response. f The difference in the WM_Score among immune phenotypes, including the inflamed (green), excluded (blue), and desert (red) immune type in the IMvigor210 cohort. (G-H) Differences in TMB (g) and neoantigen burden (h) between WM_Score-high (red) and -low (blue) groups in the IMvigor210 cohort. Wilcoxon test was used to assess the difference. The boxes indicate the median ± 1 quartile, with the whiskers extending from the hinge to the smallest or largest value within 1.5× IQR from the box boundaries

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