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Fig. 1 | Molecular Cancer

Fig. 1

From: DDX3X: structure, physiologic functions and cancer

Fig. 1

The structure of DDX3X. DDX3X can be divided into three regions: the highly conserved helicase core, the N-terminus and the C-terminus. The helicase core includes 12 signature helicase motifs that are involved in ATP binding and hydrolysis (yellow), RNA binding (green) and communication between RNA and ATP binding sites (bule). The helicase core along with the NTE and CTE are the minimal functional core of the Ded1/DDX3 subfamily. The NES residing in the N-terminus is involved in CRM-1-mediated nuclear export of DDX3X. The eIF4E binding site is located near amino acid 40. The RS-like (arginine/serine-like) region residing in the C-terminus is responsible for interacting with the nuclear export receptor TAP

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