Fig. 2

DDX3X and Translation. a DDX3X suppresses inhibition by directly binding with eIF4E to inhibit the eIF4E-eIF4G interaction. b DDX3X facilitates cap-dependent translation initiation of some RNAs that contain structured 5′UTRs by binding with the eIF4F complex. c DDX3X may facilitate translation by interacting with eIF3. d DDX3X facilitates IRES-mediated translation of viral RNAs and some cellular transcripts, the specific mechanism of which remains unclear. e DDX3X interacts with the cap-binding protein complex (CBC) and eIF3 to promote the translation of uORF-containing mRNAs. f DDX3X directly binds to (GGGGCC) n RNAs to suppress RAN translation