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Fig. 1 | Molecular Cancer

Fig. 1

From: Nanopore sequencing from liquid biopsy: analysis of copy number variations from cell-free DNA of lung cancer patients

Fig. 1

Nanopore detection of CNV from cfDNA. Fragment size distribution estimated via a Bioanalyzer, and from b Nanopore reads. NanoGLADIATOR Segmentation plots produced with NanoGLADIATOR for samples 19_1231 (cancer) and HM3 (healthy) in c “nocontrol” mode, and d “paired” mode. In “paired” mode, HF1 and HM2 have been used as controls for respectively 19_1231 and HM3. The red line indicates the segment mean (log2ratio). Each color represents a different chromosome; chromosome Y has been omitted for sample 19_123. Comparison of segmentation results: e Correlation of Nanopore and Illumina segment mean values (sample 19_744); f Comparison of Nanopore segment mean values from the full-depth BAM file and from a 2 M-reads subsampled dataset (sample 18_1130). Each genomic bin is represented as a dot, colors indicate dot density. Regression lines are shown in red. Black lines indicate the thresholds for concordant bins

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