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Fig. 7 | Molecular Cancer

Fig. 7

From: CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Fig. 7

ADAR1 overexpression reverses the suppression induced by circNEIL3 downregulation a-c. The transfection efficiency of the ADAR1 shRNA and overexpression lentivirus in CFPAC-1 and MiaPaca-2 cells was verified by RT-qPCR and western blot analyses. d-l. CCK-8, colony formation, EdU, transwell and wound healing assay results demonstrated that transfection with the ADAR1 overexpression lentivirus increased the proliferation, migration, and invasion abilities of CFPAC-1 cells, which were reduced after cotransfection with the circNEIL3 KD lentivirus. The EdU samples were imaged at 200× magnification. Scale bar = 50 μm. The transwell and hound healing samples were imaged at 100× magnification. Scale bar = 100 μm. All data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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Molecular Cancer

ISSN: 1476-4598