CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Table 1 Association of circNEIL3, miR-432-5p and ADAR1 expression with clinicopathological features of PDAC (n = 104)

Clinicopathological features	circNEIL3 expression		P value	miR-432-5p expression		P value	ADAR1 expression		P value
Clinicopathological features	High	Low	P value	High	Low	P value	High	Low	P value
All cases	52	52		52	52		52	52
Gender			0.676			0.012*			0.676
Male	36	34		29	41		34	36
Female	16	18		23	11		18	16
Age (year)			0.527			0.527			0.527
< 60	18	15		18	15		15	18
≥ 60	34	37		34	37		37	34
Serum CA199 (U/ml)			0.129			0.319			0.292
< 39	7	10		11	6		7	10
≥ 39	31	36		33	34		32	35
≥ 1000	14	6		8	12		13	7
Diameter (cm)			0.098			0.033*			0.033*
≤ 4	37	44		45	36		36	45
> 4	15	8		7	16		16	7
Location			0.094			0.403			0.676
Head	39	31		37	33		36	34
Body and tail	13	21		15	19		16	18
Histological grade			0.543			0.311			0.203
I/ I-II	34	31		35	30		32	33
II/ II-III/ III	18	21		17	22		20	19
Microscopic vascular invasion			0.02*			0.527			0.833
Present	41	30		34	37		35	36
Absent	11	22		18	15		17	16
Microscopic nerve invasion			0.014*			0.066			0.22
Present	50	42		49	43		48	44
Absent	2	10		3	9		4	8
T stage			0.168			0.844			0.554
T1/T2	25	32		29	28		27	30
T3/T4	27	20		23	24		25	22
N stage			0.325			0.554			0.076
N0	21	26		22	25		28	19
N1/N2	31	26		30	27		24	33
M stage			0.475			0.475			0.475
M0	50	52		52	50		50	52
M1	2	0		0	2		2	0
Clinical stage			0.146			0.534			0.299
I-IIa	14	21		16	19		20	15
IIb-IV	38	31		36	33		32	37

ISSN: 1476-4598