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Table 1 Association of circNEIL3, miR-432-5p and ADAR1 expression with clinicopathological features of PDAC (n = 104)

From: CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Clinicopathological features circNEIL3 expression P value miR-432-5p expression P value ADAR1 expression P value
High Low High Low High Low
All cases 52 52   52 52   52 52  
Gender    0.676    0.012*    0.676
 Male 36 34   29 41   34 36  
 Female 16 18   23 11   18 16  
Age (year)    0.527    0.527    0.527
 < 60 18 15   18 15   15 18  
 ≥ 60 34 37   34 37   37 34  
Serum CA199 (U/ml)    0.129    0.319    0.292
 < 39 7 10   11 6   7 10  
 ≥ 39 31 36   33 34   32 35  
 ≥ 1000 14 6   8 12   13 7  
Diameter (cm)    0.098    0.033*    0.033*
 ≤ 4 37 44   45 36   36 45  
 > 4 15 8   7 16   16 7  
Location    0.094    0.403    0.676
 Head 39 31   37 33   36 34  
 Body and tail 13 21   15 19   16 18  
Histological grade    0.543    0.311    0.203
 I/ I-II 34 31   35 30   32 33  
 II/ II-III/ III 18 21   17 22   20 19  
Microscopic vascular invasion    0.02*    0.527    0.833
 Present 41 30   34 37   35 36  
 Absent 11 22   18 15   17 16  
Microscopic nerve invasion    0.014*    0.066    0.22
 Present 50 42   49 43   48 44  
 Absent 2 10   3 9   4 8  
T stage    0.168    0.844    0.554
 T1/T2 25 32   29 28   27 30  
 T3/T4 27 20   23 24   25 22  
N stage    0.325    0.554    0.076
 N0 21 26   22 25   28 19  
 N1/N2 31 26   30 27   24 33  
M stage    0.475    0.475    0.475
 M0 50 52   52 50   50 52  
 M1 2 0   0 2   2 0  
Clinical stage    0.146    0.534    0.299
 I-IIa 14 21   16 19   20 15  
 IIb-IV 38 31   36 33   32 37  
  1. All data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001