CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Table 2 Univariate and multivariate analyses of prognostic factors in PDAC patients (n = 104)

Variable	Univariate analysis				Multivariate analysis
Variable	Cases	Events	Median survival (months)	P value	HR	95%CI	P value
Gender, male/ female	70/ 34	48/ 24	22.1/ 19	0.8936
Age, < 60/ ≥60	33/ 71	19/ 53	27.4/ 18.5	0.0836
Serum CA199 (U/ml)
< 39, ≥39	17/ 67	10/ 48	20.0/ 12.7	0.348
≥ 39, ≥1000	67/ 20	48/ 14	12.7/ 11.0	0.543
< 39, ≥1000	17/ 20	10/ 14	20.0/ 11.0	0.078
Location, head/ body or tail	70/ 34	49/ 23	20/ 16.9	0.4537
Diameter, ≤4/ > 4	81/ 23	51/ 21	25.3/ 9.1	< 0.0001****	1.594	1.224–2.075	0.001**
Histological grade, I, I-II/ II, II-III, III	65/ 39	44/ 28	21.9/ 19.2	0.7374
Microscopic vascular invasion, absent/ present	33/ 71	19/ 53	30.3/ 18.2	0.0146*			0.537
Microscopic nerve invasion, absent/ present	12/ 92	8/ 64	22.4/ 19.8	0.9094
T stage, T1, 2/ T3, 4	57/ 47	34/ 38	27.6/ 12.9	0.0004***			0.204
N stage, N0/ N1,2	47/ 57	30/ 42	25.3/ 18.2	0.07
M stage, M0/ M1	102/ 2	70/ 2	20/ 13.6	0.2423
Clinical stage, I-IIa/ IIb-IV	35/ 69	19/ 53	30.3/ 18.2	0.0051**	2.127	1.235–3.665	0.007**
circNEIL3 expression, low/ high	52/ 52	29/ 43	28.4/ 15.3	0.0002***	1.995	1.225–3.248	0.006**
miR-432-5p expression, low/ high	52/ 52	40/ 32	14.8/ 26.1	0.0059**			0.137
ADAR1 expression, low/ high	52/ 52	32/ 40	25.4/ 13.4	0.0023**	1.765	1.079–2.889	0.024*

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