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Table 2 Univariate and multivariate analyses of prognostic factors in PDAC patients (n = 104)

From: CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Variable Univariate analysis Multivariate analysis
Cases Events Median survival (months) P value HR 95%CI P value
Gender, male/ female 70/ 34 48/ 24 22.1/ 19 0.8936    
Age, < 60/ ≥60 33/ 71 19/ 53 27.4/ 18.5 0.0836    
Serum CA199 (U/ml)
 < 39, ≥39 17/ 67 10/ 48 20.0/ 12.7 0.348    
 ≥ 39, ≥1000 67/ 20 48/ 14 12.7/ 11.0 0.543    
 < 39, ≥1000 17/ 20 10/ 14 20.0/ 11.0 0.078    
Location, head/ body or tail 70/ 34 49/ 23 20/ 16.9 0.4537    
Diameter, ≤4/ > 4 81/ 23 51/ 21 25.3/ 9.1 < 0.0001**** 1.594 1.224–2.075 0.001**
Histological grade, I, I-II/ II, II-III, III 65/ 39 44/ 28 21.9/ 19.2 0.7374    
Microscopic vascular invasion, absent/ present 33/ 71 19/ 53 30.3/ 18.2 0.0146*    0.537
Microscopic nerve invasion, absent/ present 12/ 92 8/ 64 22.4/ 19.8 0.9094    
T stage, T1, 2/ T3, 4 57/ 47 34/ 38 27.6/ 12.9 0.0004***    0.204
N stage, N0/ N1,2 47/ 57 30/ 42 25.3/ 18.2 0.07    
M stage, M0/ M1 102/ 2 70/ 2 20/ 13.6 0.2423    
Clinical stage, I-IIa/ IIb-IV 35/ 69 19/ 53 30.3/ 18.2 0.0051** 2.127 1.235–3.665 0.007**
circNEIL3 expression, low/ high 52/ 52 29/ 43 28.4/ 15.3 0.0002*** 1.995 1.225–3.248 0.006**
miR-432-5p expression, low/ high 52/ 52 40/ 32 14.8/ 26.1 0.0059**    0.137
ADAR1 expression, low/ high 52/ 52 32/ 40 25.4/ 13.4 0.0023** 1.765 1.079–2.889 0.024*
  1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001