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Fig. 1 | Molecular Cancer

Fig. 1

From: Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk

Fig. 1

Targeted proteomic signatures differentiate molecular classes of uveal melanoma: a The vitreous contains native vitreous proteins, systemic protein biomarkers, and tumor biomarkers that can be sampled through proteomic analysis. Primary tumors can release circulating tumor markers into the vitreous and systemic circulation. Graphical illustrations by Alton Szeto and Vinit Mahajan. Permission to publish granted by original artist. b Protein concentrations from the multiplex ELISA array were normalized to log base 2 and analyzed for differentially expressed proteins. Multi-group comparison (1-way ANOVA) followed by hierarchical heat map clustering was used to identify differentially expressed proteins in the large-scale dataset. When comparing protein expression by GEP class, there were 46 differentially expressed proteins at the p < 0.01 level. Results are represented as a heatmap and display protein expression levels on a logarithmic scale. Orange indicates high expression while dark green/black indicates low or no expression. c When comparing protein expression by PRAME status, there were 32 differentially expressed proteins at the p < 0.01 level. d Comparative analysis of significantly upregulated proteins in each group (compared to controls) using Venn diagrams. e Expression of STAT3 signaling effectors identified in UM vitreous. Results are represented as a heatmap and display protein expression levels on a logarithmic scale. Samples are grouped according to their respective GEP class or PRAME status. Orange indicates high expression while dark blue indicates low or no expression

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