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Fig. 2 | Molecular Cancer

Fig. 2

From: Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk

Fig. 2

Biomarker verification study confirms expression of SCFR, HGF, and HGFR in UM vitreous: Prospective verification of 20 biomarkers in paired vitreous (UM, n = 11; control, n = 11) and plasma (UM, n = 8; control, n = 5). a Vitreous differential protein expression data are represented as a volcano plot. The horizontal axis (x-axis) displays the log2 (fold-change) in protein expression (UM vs. controls) and the vertical axis (y-axis) displays the noise-adjusted signal as the -log10 (p-value) from by Student’s pairwise t-test (Alpha = 0.05). b Expression of KLK7 sorted by PRAME status (i.e., PRAME-positive or -negative), c SCFR/c-Kit, d HGF sorted by PRAME status and e HGFR/c-Met in patient vitreous. f Plasma differential protein expression data are represented as a volcano plot. Expression of g ENPP-2 and h ARGI1 in patient plasma. Expression data is represented as protein concentration (pg/mL) and displayed as mean ± SEM. Data were analyzed by 1-way ANOVA followed by Tukey’s multiple comparison test or by Student’s pairwise t-test, where appropriate (Alpha = 0.05). i Schematic representation of verified UM vitreous biomarkers (SCFR/c-Kit, HGF, and HGFR/c-Met) and their role in pathways mediating cancer cell proliferation, survival, and differentiation. Imatinib (SCFR inhibitor) and cabozantinib (HGFR inhibitor) could be repurposed for adjuvant UM therapy

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