Table 1 mRNA species in different types of cancer
From: The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors
Cancer Type | mRNA Species | Mechanism | Function | Time (year) | Refs |
|---|---|---|---|---|---|
Glioblastoma | EGFRvIII mRNA | Unknown | Diagnosis biomarkers | 2008 | [90] |
AMACR mRNA | Unknown | Diagnosis biomarkers | 2020 | [91] | |
IGFBP2 mRNA | The occurrence of IDH1 mutation, Hsp27 expression and TERT promoter mutation | Prognostic biomarker | 2013 | [92] | |
CHI3L1 mRNA | Acts on stem cells and drive the formation of tumor vascularization | Diagnosis biomarkers | 2019 | [93] | |
Meningioma | EMP2 mRNA | Unknown | molecular marker | 2020 | [38] |
hTERT mRNA | Changes in the splicing pattern of hTERT splice variants (α-deletion and β-deletion) | prognostic biomarkers | 2019 | [94] | |
PTEN mRNA | Unknown | Low expression is used as a marker to predict malignancy | 2019 | [95] | |
Ki-67 mRNA | Unknown | High expression is used as a marker to predict malignancy | 2019 | [95] | |
Pineal region tumor | c-myc mRNA | Drives cell growth by blocking the expression of some genes associated with DNA packaging and cell death | Play a role in oncogenic processes of cancer | 2008 | |
Embryonal tumors | hTERT mRNA | Biologically aggressive tumor behavior | High expression is used as a marker to predict malignancy | 2013 | [64] |
Schwannoma | ASC mRNA | Induce apoptosis and cell cycle stagnation | Promote angiogenesis | 2019 | [83] |
ISG15 mRNA | Unknown | Diagnosis biomarkers | 2019 | [85] | |
PRICKLE1 mRNA | Unknown | Diagnosis biomarkers | 2019 | [85] | |
Erbin mRNA | Activation of the PI3K/AKT pathway | Cell proliferation | 2017 | [86] | |
ADAM9 mRNA | Unknown | Diagnosis biomarkers | 2020 | [87] | |
Medulloblastoma | VEGFR3 mRNA & PROX1 mRNA | Unknown | Regulate neuronal development & Associate with the spread of the tumor | 2020 | [65] |