Table 1 Main properties of the different families of nanovectors
From: Delivery of cancer therapies by synthetic and bio-inspired nanovectors
Nanovector family | Biocompatibility | Stealth | Immunogenicity | Ease of retargeting | Systemic injection | Frequent off-targets | Replicative | Stability | Standardized production | Cost |
|---|---|---|---|---|---|---|---|---|---|---|
Inorganic nanoparticles | Very low | Good | Low | High | Possible | Liver, spleen | No | Good | Adapted | $$$ |
Organic nanoparticles | Good | Good | Low | High | Adapted | Liver, spleen | No | Medium | Feasible | $$ |
Extracellular vesicles | High | High | None | Low | Adapted | Liver | No | Low | No | $$$ |
Bacterial minicells | High | Low | Medium | Medium | Adapted | Liver | No | Medium | Feasible | $ |
Virus-like particles | High | Medium | Medium | High | Adapted | Liver | No | Medium | Feasible | $$$ |
Oncolytic viruses | High | Medium | High | Low | Possible | Depends on virus tropism | Yes | Low | Difficult | $$$ |