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Fig. 1 | Molecular Cancer

Fig. 1

From: The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis

Fig. 1

Regulation of the m6A modification. The ‘Writers’ catalyze the transfer of methyl group from SAM to the A to introduce m6A methylation in their target transcripts while the ‘Erasers’ remove the methyl group from m6A. The ‘Reader’ proteins recognize the m6A methylation marks in the modified transcripts and determine their fate. SAM, S-Adenosyl methionine; SAH, S-Adenosyl homocysteine; METTL3, Methyl transferase-like 3; METTL14, Methyltransferase-like 14; WTAP, Wilms tumour 1-associated protein; VIRMA, Vir-like m6A methyl transferase associated protein; ZC3H13, Zinc finger CCCH domain-containing protein 13; RBM15, RNA-binding motif protein 15; FTO, Fat mass and obesity-associated protein; ALKBH5, AlkB homologue5; YTH, YT521B homology; hnRNPs, Heterogenous ribonucleoproteins; IGF2BP, Insulin-like growth factor 2 mRNA-binding protein

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