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Fig. 2 | Molecular Cancer

Fig. 2

From: CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity

Fig. 2

CircMEMO1 Inhibits HCC Cell Proliferation and Invasion In Vitro and In Vivo. a sh-circMEMO1 was overexpressed and knocked down in HCCLM3 and Huh-7 cells by lentivirus-mediated transduction, respectively. b, c Cell Counting Kit-8 (CCK-8) assays were used to determine the role of circMEMO1 in the proliferation of HCC cells. * P < 0.05; **, P < 0.01. d, e Colony formation assays showed that circMEMO1 inhibited the colony formation activity of HCC cells. f, g Transwell assays showed that circMEMO1 inhibited the migration and invasion of HCC cells. h-j Xenograft tumours composed of circMEMO1-OE HCCLM3 cells were significantly smaller than those composed of control cells. k, l circMEMO1 inhibited the lung metastasis of HCCLM3, and representative images of haematoxylin-eosin (HE) staining of metastatic nodules in the lungs of animals in different groups are shown

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Molecular Cancer

ISSN: 1476-4598