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Fig. 4 | Molecular Cancer

Fig. 4

From: CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity

Fig. 4

The circMEMO1 Level Correlates with the miR-106b-5p/TET1/5hmC Axis and Predicts a Poor Prognosis in HCC Patients. a, b The correlations between the level of circMEMO1 and mRNA levels of the TET1 and TET2 genes were analysed using qRT-PCR analysis of HCC patient samples. c, d HCC patient samples were subdivided into two groups according to the expression status of TET1. Kaplan-Meier plots representing the overall survival (c) and cumulative recurrence rate (d) of the stratified patients are shown. e Representative HCC cases in tissue microarrays (serial sections) were analysed by an in situ hybridization assay for miR-106b-5p and immunohistochemical staining for 5hmC. f, g Positive miR-106b-5p expression with a low level of 5hmC correlated with the worst survival (f) and highest recurrence rate (g) in HCC patients. I, miR-106b-5p (+); II, low 5hmC level; III, miR-106b-5p (−); IV, high 5hmC level

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Molecular Cancer

ISSN: 1476-4598