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Fig. 6 | Molecular Cancer

Fig. 6

From: CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity

Fig. 6

CircMEMO1 Inhibits HCC progression by Regulating the DNA demethylation and expression of TCF21. a, b The relationship of the TCF21 mRNA level with miR-106b-5p or CDH1 level in TCGA database. c The TCF21 mRNA level was downregulated in a series of cancers, including HCC, compared with normal tissues. d, e The TCF21 gene promoter methylation level between the HCC tissues and the controls was significantly higher in HCC patients than in controls from the same research. f, g circMEMO1 and miR-106b-5p can regulate TCF21 expression. h hMeDIP-qPCR assays showed that TCF21 genes had decreased 5hmC in gene bodies in Huh-7 and HCCLM3 cells with different circMEMO1 levels. i, j TCF21 overexpression diminished the metastasis properties and EMT process induced by inhibition of circMEMO1 or activation of miR-106b-5p

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