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Fig. 2 | Molecular Cancer

Fig. 2

From: Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients

Fig. 2

Risk and multivariate survival analyses of the colon cancer cohort (1235 tumor samples), divided in line with the CAF-related signatures. “CAF signature” (596 genes) showed prognosis value in colon cancer patients: a Distribution of risk scores from low (blue) to high (red). Risk scores were scaled from 1 to 100. The dots in gray in the middle correspond to intermediate scores; and the green line marks the point for the optimal split of samples into low- and high-risk ones; b Kaplan-Meier graph showing that the high-risk subset of patients had significantly shorter overall survival (OS) than the low-risk one (HR = 2.20; p-value = 8.34 E-15). “CAF-derived exosomes signature” (67 genes) showed prognosis value in colon cancer patients: c Distribution of risk scores from low to high; d Kaplan-Meier graph showing that the high-risk subset of patients had significantly shorter OS than the low-risk one (HR = 1.95; p-value = 7.42 E-11). Survival analysis using the top 50 genes of CAF-related signatures also found high- and low-risk patients: e Kaplan-Meier graph obtained using the top 50 genes of the “CAF-derived exosomes signature” (HR = 1.97; p-value = 4.08 E-11); f Kaplan-Meier graph with the top 50 genes of the “CAF signature” (HR = 2.22; p-value = 5.15 E-15); g Kaplan-Meier graph with the top 100 genes from the combination of both top 50s used in E and F (HR = 2.26; p-value = 1.15 E-15). In each case, the graph includes the survival traces of the patients with low risk (blue) versus the patients with high risk (red)

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