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Fig. 2 | Molecular Cancer

Fig. 2

From: KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1

Fig. 2

KDM6A inhibits BCa cell migration and invasion. a-f Migration and invasion capacities of indicated cells were examined by wound-healing assays (a, d), Transwell migration assays (b, e), and Transwell invasion assays (c, f). The normalized wound area of control cells at 0 h was set as 1. g Representative image of filopodia staining in indicated cells were shown. Scale bars, 10 μm. h Quantification of the number of filopodia per cell was shown. All quantification analyses were based on independent triplicate experiments. Error bars represent SD. i and j Lung metastasis assays of indicated T24 cells. Representative gross lung images of indicated group were shown (left). The number of tumours per lung were counted (right, Puro vs KDM6A, n = 4, NC vs shKDM6A, n = 5). Error bars represent SEM. k Representative HE staining images of the lungs were shown. Scale bars, 200 μm. l Kaplan-Meier survival curve for overall survival of patients with BCa stratified by KDM6A expression levels from tissue microarray (Cat No. HBlaU066Su01; KDM6A-low, n = 23, KDM6A-high, n = 22). *p < 0.05, **P < 0.01, ***p < 0.001, NS no significant, based on Student’s t test. Kaplan-Meier analysis based on log-rank test

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