Fig. 8
From: KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1
A schematic model showing FOXA1-KDM6A-ARHGDIB-Rac1 axis regulating BCa metastasis. FOXA1 binds to KDM6A promoter region and promotes its transcription. KDM6A can directly target the promoter region of ARHGDIB and promotes ARHGDIB transcription via demethylation of H3K27me3, antagonizing EHZ2 activity, and consequently inhibits the transformation from Rac1-GDP to active Rac1-GTP and therefore inhibits tumour metastasis