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Fig. 8 | Molecular Cancer

Fig. 8

From: GM-CSF mediates immune evasion via upregulation of PD-L1 expression in extranodal natural killer/T cell lymphoma

Fig. 8

STAT5A mutation increases the PD-L1 overexpression in the presence of GM-CSF. A A proposed working model to illustrate how GM-CSF induced disease progression in ENKTL. STAT5 mutations in ENKTL increased the auto-phosphorylation of STAT5. JAK2 hyperphosphorylation combined with STAT5 mutations led to aggressive up-regulation of PD-L1 expression after GM-CSF treatment, which could induce disease progression in ENKTL

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Molecular Cancer

ISSN: 1476-4598