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Table 3 Univariate and multivariate Cox regression analysis of circACTN4 and survival in 240 BC patients

From: The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC

Clinical variables

Univariate analysis

 

P

Multivariate analysis

P

HR

95%CI

HR95%CI

Age (≥53 vs. < 53)

1.757

1.079–2.860

0.023*

1.894

1.161–3.089

0.011*

Grade (II vs. III)

1.982

1.192–3.294

0.008**

1.989

1.194–3.316

0.008**

T stage (T1 vs. T2/3)

1.383

0.800–2.392

0.246

   

stage (N0–1 vs. N2–3)

2.234

1.327–3.758

0.002**

1.499

0.868–2.591

0.147

TNM stage (I vs. II/III)

2.937

1.182–7.299

0.020*

1.972

0.766–5.077

0.159

CircACTN4 (low vs. high)

5.040

2.913–8.720

<0.001***

4.566

2.612–7.982

<0.001***

  1. Abbreviations: HR hazard ratio, CI confidence interval
  2. *P< 0.05, **P< 0.01, ***P< 0.001