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Fig. 2 | Molecular Cancer

Fig. 2

From: Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation

Fig. 2

Integrative gene expression analysis identifies LCK as a putative driver of invasiveness of SAS subclones and metastasis formation of OSCC patients. A Volcano plot of differentially expressed genes in high invasive SAS subclones (H & S) versus weak invasive SAS subclones (F & L). B Heatmap of significantly differentially expressed genes (FDR < 0.05). C List of top 10 up/downregulated genes in the subclone analysis ranked according to log2FC. D Volcano plot of differentially expressed genes of nine matched samples of primary tumors and their respective metastasis of OSCC patients. E Heatmap of significantly differentially expressed genes in metastasis and primary tumors (FDR < 0.05). F List of top 10 up/downregulated genes in the metastasis analysis ranked according to log2FC. G Significantly (FDR < 0.05) overrepresented biological processes (Gene Ontology) of the invasive subclone analysis (left panel) and the metastasis analysis (right panel); Biological processes were grouped: the share of each group is represented in pie charts. H Venn diagram showing the overlap of differentially expressed genes from both transcriptome analyses filtered for significance of deregulation (FDR < 0.05) and absolute expression level (log2(CPM) > 2) of respective genes in SAS clones and patient samples

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Molecular Cancer

ISSN: 1476-4598