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Fig. 7 | Molecular Cancer

Fig. 7

From: Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation

Fig. 7

Prognostic relevance of LCK in HNSCC. Survival analyses were performed using the online tool GEPIA2 (http://gepia2.cancer-pku.cn/). A High LCK expression was associated with better overall survival in the TCGA HNSCC dataset. B Differential expression of LCK across individual molecular subtypes of HNSCC. C Kaplan-Meier analysis of disease-free survival in the mesenchymal subtype of HNSCC stratified by LCK mRNA abundance. D Kaplan-Meier curves for disease-free survival of OSCC patients only within the TCGA HNSCC dataset. The OSCC subgroup was first split at the median of CDH2 (CDH2high vs. CDH2low). In all groups, DFS of patients with LCKhigh and LCKlow tumors (median split) was compared. E Immunohistochemical analysis of LCK in four cases of oral cancer. Strong LCK expression was found in lymphocytes (black arrowheads). Tumor cells within the infiltration area (black arrows) show a higher LCK expression compared to the rest of the primary tumor (asterisks). Scale bars, 250 μm

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Molecular Cancer

ISSN: 1476-4598