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Fig. 2 | Molecular Cancer

Fig. 2

From: A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2–10 ng/mL at initial biopsy

Fig. 2

Performance of the Ccirc to detect high-grade PCa. Area under receiver operating characteristic curves (AUC) are shown to compare performances of the Ccirc in (A) the training cohort (n = 263), (C) the validation cohort 1 (n = 497), and (E) the validation cohort 2 (n = 505) with and without PCPT-RC, ERSPC-RC, and PSA alone. The corresponding net benefit analysis for the three cohorts is shown (B) for the training cohort, (D) for the validation cohort 1, and (F) for the validation cohort 2. Ccirc = classifier containing five circRNAs. PCa = prostate cancer. PSA = prostate-specific antigen. ERSPC-RC = European Randomized Study of Screening for Prostate Cancer risk calculator. PCPT-RC = Prostate Cancer Prevention Trial risk calculator

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Molecular Cancer

ISSN: 1476-4598