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Fig. 5 | Molecular Cancer

Fig. 5

From: CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability

Fig. 5

CircDIDO1 exerts tumor suppressor function in GC through dual mechanisms. a) Schematic diagram of mutant circDIDO1-Flag vector (circDIDO1-mut-Flag) that lacks protein-coding ability. b) Western blot assays for the expression of DIDO1-529aa in 293 T cells transfected with control, circDIDO1-Flag, circDIDO1-mut-Flag, and DIDO1-529aa-Flag vectors (detected by Flag antibody). Cell growth curve (c), colony formation (d), transwell migration (e), matrigel invasion (f) assays and flow cytometry analysis of apoptosis (g) in control, wild-type or mutant circDIDO1-Flag vector, and DIDO1-529aa-Flag vectors transfected GC cells. Data are shown as means ± SD (n = 3, **P < 0.01)

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Molecular Cancer

ISSN: 1476-4598