Fig. 1
From: Using single-cell sequencing technology to detect circulating tumor cells in solid tumors
Evolution of a metastatic cancer stem cell (CSC). As a tumour progresses, genetic and epigenetic mechanisms may result in the emergence of a selfrenewing metastatic CSC (mCSC) that expresses different cell surface markers from the CSC that is driving tumorigenesis. This mCSC, through a series of invasive processes that characterize metastasis, enters the blood stream and seeds a secondary tumour in a distinct organ [18]. The copyright of this image belongs to Reference [18].