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Table 1 Comparison of CTC single cell sorting methods

From: Using single-cell sequencing technology to detect circulating tumor cells in solid tumors

Sorting method

Sorting objects

time consuming

Advantage

shortcoming

Reference

Microoperation separation method

Less tissue and cell suspension

long

High accuracy and low cost

Time consuming, low flux, easy to cause mechanical damage to the target cells

[33, 34]

Microfluidic separation

Cell suspension with numerous cells

short

High flux, small reaction volume, less space and less pollution

High cost and high cell loss rate

[36, 39]

DEPArray sorting system

CTO solution

long

Visualization and semi automation

The sample size is small and can not be directly derived from it

[7, 40, 41]

    

Separation and enrichment of CTC in peripheral blood

 

CellCelector sorting system

CTC suspension

short

Keeping cell activity, high accuracy and less time consuming

High cost and high instrument dependence

[42]