CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia

Table 2 Univariate and multivariate analyses for relapse in all pediatric AML patients (n=87)

Variable	Univariate Analysis		Multivariate Analysis
Variable	Hazard ratio(95%CI)	P Value	Hazard ratio(95%CI)	P Value
Age	1.034(0.876-1.225)	0.698	—	—
Gender(female v male)	0.39(0.103-1.472)	0.165	—	—
WBC	0.99(0.975-1.006)	0.212	—	—
Hemoglobin	1.035(1.007-1.064)	0.014	1.036(1.002-1.07)	0.037
Platelet	1(0.997-1.004)	0.950	—	—
BM blast (above v below median)	3.514(0.753-16.392)	0.110	—	—
Clinic risk(poor v inter-mediate v favorable)	3.037(0.931-9.904)	0.066	4.135(1.088-18.443)	0.043
One course to CR(no v yes)	1.958(0.995-3.854)	0.052	1.463(0.642-3.331)	0.365
circRNF220 expression (high v low)	5.749(1.219-27.101)	0.027	5.866(1.23-27.969)	0.026

NOTE. Hazard ratios greater than or less than 1 indicate an increased or decreased risk, respectively, of an event for the first category listed
Abbreviations: WBC white blood cells, FAB French-American-British, BM bone marrow, CR complete-remission
P value from univariate or multivariate Cox proportional hazards models

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