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Fig. 9 | Molecular Cancer

Fig. 9

From: N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Fig. 9

Model of circIGF2BP3-mediated immunosuppressive effect in NSCLC. circIGF2BP3 acts as a sponge for miR-328-3p and miR-3173-5p and elevates PKP3 expression, which stabilizes OTUB1 mRNA in an FXR1-dependent manner. OTUB1 removes ubiquitin chains from PD-L1 and subsequently hinders its degradation. circIGF2BP3-induced PD-L1 upregulation in NSCLC cells ultimately promotes immune evasion and resistance to anti-PD-1 therapy

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Molecular Cancer

ISSN: 1476-4598