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Fig. 5 | Molecular Cancer

Fig. 5

From: An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks

Fig. 5

Edited CDK13 potentiates the aggressive behavior of thyroid cancer cells. Cal62 and TPC1 cells were stably infected with lentiviruses containing the WT CDK13 or its edited form (Edit CDK13) and were assayed for (A) BrdU incorporation (n = 3). B XTT dye reduction (n = 3 for Cal62 and n = 5 for TPC1) and (C) crystal violet staining (n = 4). D Matrigel Transwell invasion assay (n = 4). Error bars indicate standard deviations. Asterisks denote statistical significance compared with siControl treatment as assessed with Student’s t-test (two-tailed). * p < 0.05, ** p < 0.01, *** p < 0.001

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