Fig. 6

Edited CDK13 rescues the ADAR1-knockdown phenotype. Stably-transduced Cal62 and TPC1 cells with CDK13 Edit or Empty vector were silenced for ADAR1 and were assayed for (A) BrdU incorporation (n = 4 for Cal62 and n = 3 for TPC1 cell line). B and C Viability by XTT dye reduction (n = 3) (B) and crystal violet staining (n = 5) (C). D Matrigel Transwell invasion assay (n = 3 for Cal62 and n = 4 for TPC1 cell line). Error bars indicate standard deviations. Asterisks denote statistical significance compared with siControl treatment as assessed with Student’s t-test (two-tailed). * p < 0.05, ** p < 0.01, *** p < 0.001