Fig. 8

Edited CDK13 alters alternative splicing. RT-qPCR of ADAR1-regulated alternative splicing events for indicated genes in Cal62 (upper panel) or TPC1 cells (lower panel) stably expressing CDK13-WT, CDK13-Edit or the empty vector (n = 4). Error bars indicate standard deviations. Asterisks denote statistical significance compared with siControl treatment assessed by Student’s t-test (two-tailed). * p < 0.05, ** p < 0.01, *** p < 0.001