Skip to main content
Fig. 2 | Molecular Cancer

Fig. 2

From: DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma

Fig. 2

High DDX56 tumor expression is significantly associated with poor patient outcome in SqCLC and other cancers. a, b and c Immunohistochemical analysis showing that high DDX56 tumor protein level is associated with poor prognosis of SqCLC patients. Tissue microarrays (TMA) containing cores of 37 SqCLC were graded as exhibiting no, weak, moderate and strong DDX56 staining by a highly experienced pathologist blinded to all clinicopathologic data. Kaplan–Meier analysis comparing tumors graded as no or weak staining (low) versus those graded moderate and strong staining (high) showed that the overall survival (OS) (a) and recurrence-free survival (RFS) (b) of SqCLC patients with high DDX56 protein tumor expression is significantly lower than those with low DDX56 protein tumor expression. c Representative images of the different immunohistochemistry staining intensities. d Kaplan–Meier survival analysis of DDX56 in a published microarray gene expression dataset of 130 primary SqCLC tumor samples showed that high mRNA expression of DDX56 was significantly associated with poor OS of SqCLC patients. e-j Online survival analysis of the prognostic value of DDX56 mRNA expression in lung, gastric and liver cancers using KMplot (http://www.kmplot.com). DDX56 mRNA expression levels were shown to be significantly associated with OS (e) and progression-free survival (PFS) (f) in lung cancer patients (microarray data set, n = 1925). DDX56 mRNA expression levels were shown to be significantly associated with poor OS (g) and PFS (h) in gastric cancer patients (microarray data set, n = 875). DDX56 mRNA expression levels were shown to be significantly associated with OS (i) and PFS (j) in liver cancer patients (RNA-seq data set, n = 364)

Back to article page