Table 1 Cox univariate and multivariate analysis showing correlations between selected clinicopathologic characteristics and DDX56 IHC staining with recurrence-free survival in an independent SqCLC patient cohort (n = 56)
Variable | RFS Univariate Analysis HR (95% CI) | p | RFS Multivariate Analysis HR (95% CI) | p |
|---|---|---|---|---|
Age (≥ 60/ < 60 years) | 1.29 (0.64–2.58) | 0.47 | - | - |
Sex (female / male) | 1.36 (0.32–5.74) | 0.68 | - | - |
Stage (IIIa / IIb / IIa / Ib/ Ia) | 1.34 (1.01–1.77) | 0.039 | 1.06 (0.76–1.48) | 0.72 |
Tumor Size (> 3 cm) | 1.44 (0.65–3.17) | 0.36 | - | - |
Lymphovascular invasion (yes/no) | 1.04 (0.54–2.01) | 0.91 | - | - |
Tumor location (central/peripheral) | 1.35 (0.66–2.76) | 0.41 | - | - |
Smoke (yes/no) | 0.95 (0.37–2.5) | 0.92 | - | - |
DDX56 staining (strong or moderate/ weak or negative) | 3.02 (1.40–6.53) | 0.005 | 2.74 (1.07–7.02) | 0.036 |