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Fig. 6 | Molecular Cancer

Fig. 6

From: A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation

Fig. 6

circPLCE1 inhibits CRC cell proliferation and metastasis in vivo.A Representative images of gross inspection and H&E staining of the CRC orthotopic tumors or liver metastasis tumors (n = 5 per group). Orthotopic tumors scale bars = 0.5 cm, H&E scale bars = 100 μm. B Orthotopic xenograph CRC tumor formation and liver metastasis analysis. C Statistical analysis of orthotopic tumor volumes. D qRT-PCR analysis of human HPRT mRNA relative to mouse 18S rRNA in the livers of orthotopic xenograft CRC models. E and F Growth curves and tumor weight of PDX model tumors after treatment with vector, circPLCE1, circPLCE-ATGmut or circPLCE1-411 lentivirus (n = 5 per group). G and H H&E, circPLCE1, RPS3 and p-P65 staining in PDX model tumors mentioned above. scale bars = 200 μm. Values are represented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ns (no significance), by one-way ANOVA

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Molecular Cancer

ISSN: 1476-4598