Fig. 2
The immuno-oncological features and clinical significance of m6A regulators in small cell lung cancer. a Network diagram displays the relationship between the selected m6A regulators and cancer hallmark-related pathways in small cell lung cancer from the International Cohort. The red and blue lines represent positive and negative correlations, respectively. b Correlations between the expression of each m6A regulator in small cell lung cancer from the International Cohort. The scatter plot shows the highest correlation coefficient group (VIRMA and YTHDF3, Pearson R = 0.81). c Protein–protein interactions among the m6A regulators. d The relationship between m6A regulators and inflammatory activities in small cell lung cancer from the International Cohort. e Correlation of m6A regulators and tumor purity, the fraction of stromal cells, and immune cell populations in small cell lung cancer from the International Cohort. f Association between the m6A regulators and immune checkpoint profile in small cell lung cancer from the International Cohort. g Effects of the 11-regulator based m6A score on overall survival of 77 patients from training cohort with RNA-seq data (International Cohort). h Validation of m6A score in 48 patients from the Shanghai Cohort with RNA-seq data. i Validation of the m6A score in 152 formalin-fixed paraffin-embedded samples with qPCR data from the NCC Cohort. *, **, and *** represent P < 0.05, P < 0.01, and P < 0.001, respectively