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Table 1 Exosomes related with lung cancer metastasis by EMT

From: Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms

Cancer type Exosomes source Related genes or pathway Tissues and/or cells Experimental data Function Refs
Lung cancer Cell culture fluid SNAI1 Lung cancer cells Promote cells EMT by CAFs deliver SNAI1 to recipient cancer cells via exosomes Promote EMT [19]
Lung cancer (NSCLC) Cell culture fluid ZEB1 HBEC cell model Exosomes transfer chemoresistance and mesenchymal phenotypes to recipient cells. Promote EMT [20]
Lung cancer (NSCLC) Cell culture fluid TRAF4 Lung fibroblasts By stabilize NOX complex to promote the proliferation and EMT of NSCLC cells Promote EMT [21]
Lung cancer Cell culture fluid TGF-β1; Smad2/3; Akt/GSK-3β/β-catenin; NF-κB; ERK; JNK and p38 MAPK MSCs Promotes EMT, invasion, and migration; enhance the anti-proliferation and pro-apoptotic effect of MSCs on lung cancer cells Promote EMT [22]
Lung cancer Cell culture fluid TGF-β1; specific miRNAs of exosomes Lung cancer cells (A549 and H1299 cells) Promote migration, invasion and expression of mesenchymal markers in the recipient cells Promote EMT [23]
Lung cancer Hypoxic BMSCs fluid miR-193a-3p; miR-210-3p; miR-5100; STAT3 signaling Lung cancer cells Exosomes miRNAs activate STAT3 signaling pathway Promote EMT [24]
Lung cancer Cell culture fluid miR-210-3p; FGFRL1 Lung CSCs Promotes EMT, and through miR-210-3p combining FGFRL1 enhance the metastatic ability of lung cancer cells Promote EMT, [25]
Lung cancer Cell culture fluid; Serum   Lung cancer cells and human late stage lung cancer serum Promote EMT Promote EMT [26]
  1. Abbreviations: BMSCs Bone marrow-derived mesenchymal stem cells, CAFs Cancer-associated fibroblasts, CSCs Cancer stem cells, EMT Epithelial-mesenchymal transition, FGFRL1 Fibroblast growth factor receptor-like 1, MSCs Mesenchymal stem cells, NSCLC Non-small cell lung cancer