Table 1 Exosomes related with lung cancer metastasis by EMT
From: Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms
Cancer type | Exosomes source | Related genes or pathway | Tissues and/or cells | Experimental data | Function | Refs |
|---|---|---|---|---|---|---|
Lung cancer | Cell culture fluid | SNAI1 | Lung cancer cells | Promote cells EMT by CAFs deliver SNAI1 to recipient cancer cells via exosomes | Promote EMT | [19] |
Lung cancer (NSCLC) | Cell culture fluid | ZEB1 | HBEC cell model | Exosomes transfer chemoresistance and mesenchymal phenotypes to recipient cells. | Promote EMT | [20] |
Lung cancer (NSCLC) | Cell culture fluid | TRAF4 | Lung fibroblasts | By stabilize NOX complex to promote the proliferation and EMT of NSCLC cells | Promote EMT | [21] |
Lung cancer | Cell culture fluid | TGF-β1; Smad2/3; Akt/GSK-3β/β-catenin; NF-κB; ERK; JNK and p38 MAPK | MSCs | Promotes EMT, invasion, and migration; enhance the anti-proliferation and pro-apoptotic effect of MSCs on lung cancer cells | Promote EMT | [22] |
Lung cancer | Cell culture fluid | TGF-β1; specific miRNAs of exosomes | Lung cancer cells (A549 and H1299 cells) | Promote migration, invasion and expression of mesenchymal markers in the recipient cells | Promote EMT | [23] |
Lung cancer | Hypoxic BMSCs fluid | miR-193a-3p; miR-210-3p; miR-5100; STAT3 signaling | Lung cancer cells | Exosomes miRNAs activate STAT3 signaling pathway | Promote EMT | [24] |
Lung cancer | Cell culture fluid | miR-210-3p; FGFRL1 | Lung CSCs | Promotes EMT, and through miR-210-3p combining FGFRL1 enhance the metastatic ability of lung cancer cells | Promote EMT, | [25] |
Lung cancer | Cell culture fluid; Serum | Â | Lung cancer cells and human late stage lung cancer serum | Promote EMT | Promote EMT | [26] |