CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner

Table 1 Relationships between circMYH9 expression and the clinicopathological characteristics of CRC patients

Variables	Cases	circMYH9 expression		P value	χ²
Variables	Cases	Low(n = 74)	High(n = 74)	P value	χ²
Age (years)
≤ 62 years	91	46	45	0.866	2.244
> 62 years	57	28	29	0.866	2.244
Gender
Female	71	39	32	0.249	0.101
Male	77	35	42	0.249	0.101
Tumor size
≤ 5.0 cm	76	30	46	0.009^**	0.000
> 5.0 cm	72	44	28	0.009^**	0.000
Distant metastasis
Negative	129	69	60	0.027^*	0.001
Positive	19	5	14	0.027^*	0.001
Differentiation
Poor	59	26	33	0.240	0.093
Well to moderate	89	48	41	0.240	0.093
Lymph node metastasis
Negative	76	45	31	0.021^*	0.001
Positive	72	29	43	0.021^*	0.001
TNM stage
I–II	78	46	32	0.021^*	0.001
III–IV	70	28	42	0.021^*	0.001
MSI status
MSI-H	11	4	7
MSI-L/MSS	137	70	69	0.347	0.202
p53 status
Negative	60	23	37
Positive	88	51	37	0.019^*	0.001

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