Fig. 3

Crosstalk of m6A with circular RNAs. m⁶A modification is involved in the life cycle of circRNAs. First, m⁶A modification on pre-mRNAs may influence the splicing and generation of circRNAs. Second, m⁶A modification on mature circRNAs could affect the nuclear exportation of circRNAs. Third, m⁶A modification on circRNAs may influence the molecular functions of circRNAs, including transcription regulation, miRNA sponging, RBP binding and translation. Fourth, m⁶A modification may influence circRNA degradation or even entering the exosomes. Also, circRNAs can regulate m⁶A by affecting the expression or the functions of the m⁶A writers, erasers and readers. There are some predicted interactions between m⁶A and circRNAs have not been validated yet, which are marked with “?” in the figure