Fig. 5

Clinical relevance of SAA2 and CFB expression in the UroCCR cohort. a Overall Survival (OS) of patients stratified according to SAA2 (HR(log-rank) = 2.901 (1.526–5.517)) or CFB gene expression (HR(log-rank) = 2.556 (1.24–5.267); n = 89). b Disease-Free Survival (DFS) of patients stratified according to SAA2 (HR(log-rank) = 2.342 (1.211–4.529)) or CFB gene expression (HR(log-rank) = 2.846 (1.323–6.123); n = 104). c qPCR analysis of tissues deriving from primary tumors or adjacent normal tissues. d Gene expression of SAA2 and CFB in patient’s tumor tissue stratified according to low Fuhrman grade (1–2), grade 3 and grade 4, compared to adjacent normal tissues. e and f ELISA experiment showing plasma levels of SAA2 and CFB, in non-metastatic (M0) and metastatic (M1) patients at the moment of diagnosis, before and after surgery, respectively. g Disease-Free Survival (DFS) of patients stratified according to SAA2 (HR(log-rank) = 8.191 (2.04–32.891); Low, n = 9; High, n = 9) or CFB (HR(log-rank) = 2.545 (0.578–11.201); Low, n = 8; High, n = 9) plasma levels before surgery (i.e. primary tumor resection). h Overall Survival (OS) of patients stratified according to SAA2 (HR(log-rank) = Inf, not calculable) or CFB (HR(log-rank) = 0.875 (0.123–6.237)) plasma levels after surgery (i.e. primary tumor resection). Low, n = 9; High, n = 10