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Table 1 Patient baseline characteristics at time of sampling

From: Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

Subject ID

scRNA-seq

FACS/RT-PCR

Samples biopsied for scRNA-seq

Age

Sex

Ethnicity

Diagnosis

Large cell transformation

Disease duration (years)

Ongoing treatment

Previous treatments

Disease stage

MF309

x

x

Patch and tumor (trunk)

76

Male

Caucasian

CD4+ MF, CD30+

Present

Diagnosis 22 years ago; symptoms reported since age 37

ECP

Topical GCS, IFN alpha

IVA1 (T3N0M0B2)

MF309

x

 

Ulcerated tumor (follow-up lesion trunk) and nonlesional skin (trunk)

76

  

CD4+ MF, CD30+

Present

 

ECP

Brentuximab

IVA1 (T3N0M0B2)

MF311

x

x

Patch and plaque (trunk)

74

Female

Caucasian

CD4 + MF, CD30-

Absent

Diagnosis 2 years ago; symptoms reported since age 53

ECP

NB-UVB, bexarotene, PUVA, topical and systemic GCS, IFN alpha, alemtuzumab, local radiotheraphy (x ray)

IVA1 (T2N1M0B2)

MF311

x

 

Nonlesional skin (lower extremity)

74

  

CD4 + MF, CD30-

Absent

 

ECP

 

IVA1 (T2N1M0B2)

MF311

x

 

Erythroderma (follow-up lesion upper extremity)

75

  

CD4 + MF, CD30-

Absent

 

ECP, chlorambucil, systemic GCS

 

IVA1 (T4N1M0B2)

MF312

x

 

Patch and plaque (upper extremity)

55

Male

Caucasian

CD4 + MF, CD30+

Present

Diagnosis 6 years ago; symptoms since age 44

ECP, IFN alpha, acitretin

Topical GCS, NB-UVB, local radiotherapy (x ray)

IIB* (T2bN0M0B0)

MF312

x

 

Cleared (follow-up) lesion (upper extremity)

56

   

n.a.

 

ECP, chlormethine

 

IIB* (T1aN0M0B0)

MF318

x

 

Patch and plaque (thigh)

55

Female

Caucasian

gamma/delta MF, CD30+

Absent

Symptoms since age 52; recently diagnosed

none

Topical GCS and CNI, NB-UVB

IIB** (T3N0M0B0)

P65

x

 

Patch and non-lesional skin (upper extremity)

53

Male

Caucasian

CD4 + MF, CD30-

Absent

Symptoms for > 10 years; recently diagnosed

none

Topical GCS

IB (T2aN0M0B0)

P107

x

 

Patch lower back

39

Female

Caucasian

CD4−/CD8-MF, CD30+

Absent

Symptoms for > 20 years; diagnosed at age 37

none

Topical GCS

IA (T1bN0M0B0)

P107

 

x

Plaque lower back

39

Female

Caucasian

CD4−/CD8-MF, CD30+

Absent

Symptoms for > 20 years; diagnosed at age 37

none

Topical GCS

IA (T1bN0M0B0)

P138

x

 

Patch thigh

47

Male

Caucasian

CD4 + MF

Absent

Symptoms for > 20 years; recently diagnosed

none

Topical GCS

IA (T1aN0M0B0)

P73

x

 

Plaque and non-lesional skin (lower extremity)

82

Male

Caucasian

folliculotropic MF, CD30-

Absent

Diagnosis 6 years ago

none

PUVA, topical GCS, Re-PUVA, local radiotherapy

IIB (T3N0M0B0)

P84

x

 

Plaque (upper extremity)

75

Male

Caucasian

CD4 + MF, CD30-

Absent

Symptoms for 6 months; recently diagnosed

none

NB-UVB, topical GCS

IIB (T3N0M0B1)

P84

x

 

Cleared (follow-up) lesion (upper extremity)

75

  

CD4+ MF, CD30-

Absent

 

PUVA

 

IIB (T3N0M0B1)

P90

x

 

Patch and non-lesional skin (upper extremity)

75

Male

Caucasian

CD4 + MF

Absent

Diagnosis at age 64

none

topical GCS, PUVA, NB-UVB, bexarotene, acitretin

IB (T2aN0M0B0)

P15

 

x

Tumor trunk

59

Male

Caucasian

CD4 + MF, CD30+

Present

Diagnosis at age 56

Brentuximab vedotin

Topical and systemic GCS

IIB (T3N0M0B0)

P182

 

x

Patch and plaque (trunk)

49

Female

Caucasian

CD4 + CD8 + MF, CD30+

Absent

Onset of symptoms 4 months ago, recently diagnosed

none

none

IA (T1bN0M0B1)

P112

x

 

Healthy control skin

51

Female

Caucasian

n.a.

n.a.

n.a.

none

n.a.

n.a.

P115

x

 

Healthy control skin

48

Male

Caucasian

n.a.

n.a.

n.a.

none

n.a.

n.a.

P116

x

 

Healthy control skin

57

Female

Caucasian

n.a.

n.a.

n.a.

none

n.a.

n.a.

P121

x

 

Healthy control skin

44

Female

Caucasian

n.a.

n.a.

n.a.

none

n.a.

n.a.

  1. ECP Extracorporeal photopheresis, GCS glucocorticosteroids, IFN interferon, PUVA psoralen ultraviolet A photochemotherapy, NB-UVB narrow band ultraviolet B phototherapy, CNI calcineurin inhibitor, MF mycosis fungoides; *history of skin tumors successfully treated with local radiotherapy, ** tumor was not biopsied, only patch and plaque