Skip to main content
Fig. 3 | Molecular Cancer

Fig. 3

From: The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis

Fig. 3

Epigenetic bookmarking. During early mitosis, the acetylation of histone H4 in lysine 5 (H4K4Ac) increases. BRD4-L is recruited to the chromatin and binds to lysine-acetylated histones (Ac). After mitotic division, BRD4-L bound to chromatin is transmitted to daughter cells and promotes rapid post-mitotic transcriptional re-activation of genes regulating M/G1 transition of the cell cycle

Back to article page

Molecular Cancer

ISSN: 1476-4598