Fig. 4From: The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesisThe role of BRD4 in chromatin organization and gene transcription. BRD4-L and BRD4-S bind to lysine-acetylated histones (Ac) to maintain the higher order of chromatin. Treatments that prevent binding of BRD4-L/S to chromatin induce the chromatin fragmentation. BRD4-L promotes histone acetylation (HAT) recruiting more BRD4-L molecules. BRD4-L associates with the positive transcription elongation factor b (P-TEFb). BRD4-L and P-TEFb re-activate gene transcription via pause release of the RNA polymerase II (RNA Pol II). BETi: Bromodomain inhibitors; BRD4-KD: BRD4 knockdownBack to article page