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Fig. 2 | Molecular Cancer

Fig. 2

From: Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer

Fig. 2

Schematic diagram of dCas9-based gene editing tools. a CRISPRa: Fusion of deactivated Cas9 (dCas9) with activation domain VP64 induces the expression of gene of interest. b CRISPRi: Fusion of dCas9 with repressor domain KRAB leads to inhibition of gene of interest. c Base editing: Fusion of dCas9 with adenosine deaminase or cytidine deaminase enable introduction of point mutation in the genome

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Molecular Cancer

ISSN: 1476-4598