Fig. 2
From: Proteolysis-targeting chimeras (PROTACs) in cancer therapy
The emerging new concepts of PROTAC technologies. a photoswitchable PROTAC (upper) achieves reversible optical control of protein degradation by interconverting between inactive and active conformers, and photocaged PROTAC (lower) irreversibly achieves light-induced protein degradation by removing photocaging group. b CLIPTAC can be formed intracellularly through click combination of two tagged precursors. c HaloPROTAC and dTAG system utilize tag fusion POI and ligand that bind to tag protein