From: Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Target | PROTAC | PROTAC structure | Cancer | Ref | Target | PROTAC | PROTAC structure | Cancer | Ref |
---|---|---|---|---|---|---|---|---|---|
PD-L1 | P22 |
| NSCLC TNBC, M | [215] | FKBP12 | dFKBP-1 |
| AML | [12] |
BTK | DD-04-015 |
| DLBCL | [161] | FKBP12 | dTAG-13 |
| AML | [225] |
BTK | P13I |
| BL, DLBCL, MCL | [216] | FKBP12 | RC32 |
| T-ALL, BL, PC, BC, CC | [226] |
BTK | RC-3 |
| BL, MCL, CML | [217] | FKBP12 | KB02-SLF |
| / | [97] |
BTK | RC-1 |
| AML, MCL | [227] | HPK1 | SS44 |
| BL, MM, CML, et al | [220] |
BTK | BC5P |
| AML | [219] | IDO1 | degrader 2c |
| CC | [221] |
BTK | DD-03-171 |
| MCL, DLBCL | [218] | IKZF1/3 | DD-03-171 |
| MCL, DLBCL | [218] |
BTK | compound 10 |
| BL, AML | [228] | IRAK4 | degrader-5 |
| DLBCL | [229] |
BTK | PROTAC 7 |
| BL, CML | [118] | ITK | TL12-186 |
| AML, T-ALL | [161] |
STAT3 | SD-36 |
| AML, ALCL | [57] | JAK | JP-6 |
| AML | [222] |
CD147 | compound 6a |
| M | [230] | Lin28 | ORN3P1 |
| CML | [18] |
PDE4 | SNIPER(PDE4)-9 |
| FS | [89] | PRC2 | PROTAC 1 |
| DLCBL | [231] |
PDEδ | compound 17f |
| CRC | [232] | PRMT5 | MS4322 |
| BC | [233] |
PDEδ | PROTAC 3 |
| T-ALL, PaC, CC | [234] | Rpn13 | WL-40 |
| MM | [235] |
Pirin | CCT367766 |
| OC | [236] | SHP2 | SHP2-D26 |
| EC, AML | [223] |
PRC2 | UNC6852 |
| CC, DLCBL | [237] | TBK1 | PROTAC 3i |
| NSCLC | [238] |